| The Metropolitan Atlanta Congenital Defects Program: 35 years of birth defects surveillance at the Centers for Disease Control and Prevention. | |
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MedLine Citation:
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PMID: 14703783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Metropolitan Atlanta Congenital Defects Program (MACDP) is a population-based birth defects surveillance program administered by the Centers for Disease Control and Prevention (CDC) that has been collecting, analyzing, and interpreting birth defects surveillance data since 1967. This paper presents an overview of MACDP current methods and accomplishments over the past 35 years. METHODS: MACDP actively monitors major birth defects among infants born to residents of five counties of metropolitan Atlanta, an area with approximately 50,000 annual births. Cases are ascertained from multiple sources, coded using a modified British Pediatric Association six-digit code, and reviewed and classified by clinical geneticists. RESULTS: MACDP has monitored trends in birth defects rates and has served as a case registry for descriptive, risk factor, and prognostic studies of birth defects, including studies of Agent Orange exposure among Vietnam War veterans, maternal use of multivitamins, diabetes, febrile illnesses, and survival of children with neural tube defects. MACDP has served as a data source for one of the centers participating in the National Birth Defects Prevention Study, and for developing and evaluating neural tube defects prevention strategies related to the periconceptional use of folic acid supplements. CONCLUSIONS: Since its inception, MACDP has served as a resource for the development of uniform methods and approaches to birth defect surveillance across the United States and in many other countries, monitoring birth defects rates, and as a case registry for various descriptive, etiologic, and survival studies of birth defects. MACDP has also served as a training ground for a large number of professionals active in birth defects epidemiology. |
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Authors:
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Adolfo Correa-Villaseñor; Janet Cragan; James Kucik; Leslie O'Leary; Csaba Siffel; Laura Williams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 67 ISSN: 1542-0752 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2004-01-05 Completed Date: 2004-05-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 617-24 Citation Subset: IM |
Affiliation:
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Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. acorrea@cdc.gov |
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| MeSH Terms | |
Descriptor/Qualifier:
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2,4,5-Trichlorophenoxyacetic Acid
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toxicity 2,4-Dichlorophenoxyacetic Acid / toxicity Centers for Disease Control and Prevention (U.S.)* / standards* Congenital Abnormalities / classification, diagnosis*, epidemiology*, etiology, prevention & control Defoliants, Chemical / toxicity Diabetes Mellitus / physiopathology Environmental Exposure / adverse effects Folic Acid / therapeutic use Forms and Records Control / standards Georgia / epidemiology Medical Records Neural Tube Defects / prevention & control Prognosis Registries / statistics & numerical data Retrospective Studies Risk Factors Seizures, Febrile / physiopathology Sentinel Surveillance* Tetrachlorodibenzodioxin / toxicity United States Urban Population Veterans / statistics & numerical data Vitamins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Defoliants, Chemical; 0/Vitamins; 1746-01-6/Tetrachlorodibenzodioxin; 39277-47-9/Agent Orange; 59-30-3/Folic Acid; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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