Document Detail


Metronidazole-induced pancreatitis. A case report and review of literature.
MedLine Citation:
PMID:  15536294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far. CASE REPORT: We report a case of recurrent acute pancreatitis in a 46-year-old female associated with oral metronidazole therapy and review the literature with regards to metronidazole-induced pancreatitis. We are also highlighting the fact that the time lag between metronidazole exposure and development of pancreatitis is very variable. CONCLUSION: High degree of suspicion is warranted on the part of physicians to diagnose metronidazole induced pancreatitis in patients presenting with gastrointestinal symptoms after metronidazole exposure. If metronidazole is suspected as the causative agent then it should be discontinued and rechallenge should be avoided.
Authors:
Sagar U Nigwekar; Kevin J Casey
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2004-11-10
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  5     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-10     Completed Date:  2005-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  516-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Rochester General Hospital, Rochester, NY 14621, USA. sagar.nigwekar@viahealth.org
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MeSH Terms
Descriptor/Qualifier:
Diagnostic Errors
Female
Humans
Metronidazole / adverse effects*,  therapeutic use
Middle Aged
Pancreatitis / chemically induced*,  diagnosis
Pancreatitis, Alcoholic / diagnosis
Recurrence
Time Factors
Vaginosis, Bacterial / drug therapy
Chemical
Reg. No./Substance:
443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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