| Metronidazole in treatment against Haemophilus vaginalis (Corynebacterium vaginale). | |
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MedLine Citation:
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PMID: 6968175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rate of bactericidal activity and inactivation of metronidazole was studied in time-kill curves with Haemophilus vaginalis (Corynebacterium vaginale). The minimum inhibitory concentrations of metronidazole for the eight strains tested ranged from 4 to 16 micrograms/ml. At a concentration of 20 micrograms/ml, metronidazole demonstrated a slow cidal effect against exponential-phase organisms, requiring 24 to 48 h for completion. Inactivation of metronidazole during the time-kill curve was quite variable and averaged 28% of the starting concentration after 48 h. Against stationary-phase organisms (inoculum, 10(10) to 10(11) colony-forming units per ml), a slow cidal effect was also seen, with an average inactivation of metronidazole of 38% after 48 h. At a subinhibitory concentration of 5 micrograms/ml, metronidazole was inactivated to the greatest degree (57% after 48 h). Therefore, in contrast to earlier studies in which metronidazole was rapidly and consistently cidal within 4 h against obligate anaerobes and was almost completely inactivated by 8 h, the bactericidal effect of metronidazole againsts H. vaginalis in this study was much slower and was associated with a variable and slower rate of inactivation. |
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Authors:
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E D Ralph; Y E Amatnieks |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 18 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-11-20 Completed Date: 1980-11-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gardnerella vaginalis
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drug effects* Haemophilus / drug effects* Haemophilus Infections / drug therapy Humans Metronidazole / metabolism, pharmacology*, therapeutic use Microbial Sensitivity Tests Time Factors |
| Chemical | |
Reg. No./Substance:
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443-48-1/Metronidazole |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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