Document Detail

Metronidazole in head and neck surgery--the effect of lengthened prophylaxis.
MedLine Citation:
PMID:  2126114     Owner:  NLM     Status:  MEDLINE    
Previous studies of antibiotic prophylaxis have shown that treatment for 24 hours has been beneficial for head and neck surgery and that longer periods of antibiotic therapy have not improved results. Metronidazole (Flagyl), unlike other antibiotics tested, has been shown to be effective in an experimental abscess, even if treatment is begun up to 120 hours after administration of inoculum. This article presents a prospective, randomized, multifactorial study comparing a brief vs. a prolonged duration of metronidazole and cefazolin prophylaxis in 50 consecutive patients with a head and neck cancer undergoing operation. Patients receiving 2 days vs. 7 or more days of antibiotic prophylaxis were compared. Statistical analysis of data demonstrated a striking reduction in severity of wound complications and a reduced incidence of wound infections in the group treated with 7 or more days of antibiotic prophylaxis.
R Sawyer; L Cozzi; D I Rosenthal; A J Maniglia
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  103     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-01     Completed Date:  1991-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1009-11     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21205.
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MeSH Terms
Aged, 80 and over
Cefazolin / administration & dosage,  therapeutic use*
Head / surgery*
Metronidazole / administration & dosage,  therapeutic use*
Middle Aged
Neck / surgery*
Prospective Studies
Risk Factors
Surgical Flaps
Surgical Wound Infection / prevention & control*
Time Factors
Reg. No./Substance:
25953-19-9/Cefazolin; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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