| Metoprolol and propranolol in migraine prophylaxis: a double-blind multicentre study. | |
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MedLine Citation:
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PMID: 6391066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind, cross-over multicentre trial, the prophylactic antimigraine effect of the beta 1-selective beta-blocker metoprolol was evaluated and compared with that of the non-selective beta-blocker propranolol. Metoprolol was used in a dosage of 50 mg b.i.d. and propranolol in 40 mg b.i.d. 56 patients with classical or common migraine were included in the double-blind part of the investigation. 3 patients withdrew, but none because of side-effects. The data suggest that metoprolol is clinically equivalent in effectiveness to propranolol in migraine prophylaxis regarding parameters such as attack frequency, improvement in sum of severity score and subjective evaluation. Both drugs were generally well tolerated and the number of reported side-effects was similar to those reported during the run-in period (placebo). |
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Authors:
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J E Olsson; H C Behring; B Forssman; C Hedman; G Hedman; F Johansson; J Kinnman; S E Pålhagen; M Samuelsson; E Strandman |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 70 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-12-26 Completed Date: 1984-12-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 160-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analgesics / therapeutic use Clinical Trials as Topic Double-Blind Method Ergotamine / therapeutic use Female Hemodynamics / drug effects Humans Male Metoprolol / adverse effects, therapeutic use* Middle Aged Migraine Disorders / prevention & control* Propranolol / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 113-15-5/Ergotamine; 37350-58-6/Metoprolol; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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