Document Detail

Metoprolol and pindolol in hypertension: different effects on peripheral haemodynamics.
MedLine Citation:
PMID:  7318347     Owner:  NLM     Status:  MEDLINE    
1. Thirty-six patients with essential hypertension, were randomly allocated to double-blind treatment with either metoprolol (100--200 mg/day) or pindolol (5--10 mg/day). The effects upon blood pressure and peripheral blood flow were determined. Both drugs reduced blood pressure significantly. 2. Heart rate was significantly reduced by metoprolol but not by pindolol. 3. Vascular resistance at maximal dilatation was not changed by either pindolol. 4. At rest, pindolol reduced vascular resistance in the calf by 14% (P less than 0.05) but metoprolol tended to increase the resistance slightly. The difference in effect was also significant (P less than 0.005). 5. During leg muscle work there were no changes in vascular resistance in the forearm with either compound. 6. We conclude that pindolol appears to reduce blood pressure at least partly through vascular mechanisms, in contrast to metoprolol. The response to sympathetic stimulation induced by physical exercise does not differ between metoprolol- and pindolol-treated patients.
A Svensson; T Gudbrandsson; R Sivertsson; L Hansson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  61 Suppl 7     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  425s-427s     Citation Subset:  IM    
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MeSH Terms
Double-Blind Method
Hemodynamics / drug effects*
Hypertension / drug therapy*
Metoprolol / therapeutic use*
Middle Aged
Pindolol / therapeutic use*
Propanolamines / therapeutic use*
Random Allocation
Reg. No./Substance:
0/Propanolamines; 13523-86-9/Pindolol; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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