Document Detail

Metoprolol minimizes nighttime blood pressure dip in hypertensive black males.
MedLine Citation:
PMID:  7794574     Owner:  NLM     Status:  MEDLINE    
Twelve hypertensive black males completed the study, which was conducted to evaluate the effect of metoprolol on 24-h ambulatory blood pressure (ABP). Study participants took 50 mg to 100 mg metoprolol twice daily for a minimum of 3 weeks. Metoprolol had no significant effect on blood pressure (147/90 +/- 11/8 mm Hg v 151/88 +/- 16/8 mm Hg, baseline v treated, respectively) in spite of causing significant reductions in heart rate (87 +/- 9 beats/min v 69 +/- 7 beats/min, P < .001). Only one subject had a > or = 10 mm Hg decrease in 24-h diastolic blood pressure. The nighttime fall in blood pressure was minimized by metoprolol and clinically significant increases in daytime or nighttime blood pressure were noted in 58% of patients. Metoprolol therapy failed to lower blood pressure and eliminated the normal nighttime decline in blood pressure. Since the nighttime decline in blood pressure is thought to protect against target organ damage, it may be important to identify antihypertensive agents which preserve or enhance the nighttime blood pressure dip.
J A Johnson; W S Akers; S T Miller; W B Applegate
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  8     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
Department of Clinical Pharmacy, College of Pharmacy, University of Memphis 38163, USA.
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MeSH Terms
African Continental Ancestry Group
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology
Hypertension / drug therapy*,  physiopathology*
Metoprolol / therapeutic use*
Middle Aged
Reg. No./Substance:

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