| Metoprolol, but not atenolol, reduces stress induced neuropeptide Y release in pigs. | |
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MedLine Citation:
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PMID: 21080845 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: To explore if β-adrenergic receptors in the brain are involved in acute and delayed cardiovascular responses to a brief emotional stress, by comparing the effects of the β1-blockers metoprolol (lipophilic) and atenolol (hydrophilic). DESIGN: Male dominant pigs, singleliving, freely moving, with telemetric recordings of intra-arterial pressure and ECG and assay of plasma levels of the adrenergic cotransmitter neuropeptide Y (NPY), were confronted with four alien pigs for three minutes at weekly intervals. Weeks 1 and 4 were controls, in weeks 2 and 3 randomized crossover treatment with metoprolol or atenolol were given. RESULTS: The confrontation caused instant and transient tachycardia and more prolonged effects in terms of increased plasma NPY levels, increased arterial pressure and reduced cardiac vagal activation. The two β-blockers inhibited the tachycardia equally, but only metoprolol reduced the prolonged effects. CONCLUSIONS: Emotionally induced sympathetic activation involves peripheral release of NPY causing a prolonged increase of arterial pressure and a reduction of cardiac vagal activity. These effects are prevented by central nervous β-adrenoceptor blockade. |
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Authors:
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Bengt Åblad; Thorvald Bjurö; Jan-Arne Björkman; Owe Brax; Lars Ewaldsson; Eva Forshult; Lena Lidfors; Jan M Lundberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 44 ISSN: 1651-2006 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 273-8 Citation Subset: IM |
Affiliation:
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AstraZeneca R&D, Mölndal, Sweden. bengtablad@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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