| Göteborg Metoprolol Trial: tolerance. | |
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MedLine Citation:
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PMID: 6731329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During a 3-month follow-up, 131 patients (19.1%) withdrew from blind treatment in both metoprolol- and placebo-treated groups. More metoprolol-treated than placebo-treated patients withdrew because of cardiovascular adverse experience mainly during the very early phase. In all, 45 (6.5%) metoprolol-treated vs 14 (2.0%) placebo-treated patients were not given either a full intravenous dose or a full oral dose 15 minutes later. Bradycardia and hypotension were more common in the metoprolol group, whereas severe atrioventricular block did occur in a similar number of patients in both groups and severe congestive heart failure was more common in the placebo group. Results indicate that tolerance is generally good after intravenous and oral treatment with metoprolol in patients with suspected acute myocardial infarction. |
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Authors:
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J Herlitz; K Pennert; H Wedel; A Vedin; C Wilhelmsson; L Wilhelmsen; A Hjalmarson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 53 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-25 Completed Date: 1984-07-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 46D-50D Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Blood Pressure / drug effects Clinical Trials as Topic* Double-Blind Method Drug Tolerance Heart Block / etiology Heart Failure / etiology Heart Rate / drug effects Humans Hypertension / etiology Injections, Intravenous Metoprolol / pharmacology, therapeutic use* Myocardial Infarction / complications, drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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37350-58-6/Metoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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