Document Detail


Göteborg Metoprolol Trial: tolerance.
MedLine Citation:
PMID:  6731329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During a 3-month follow-up, 131 patients (19.1%) withdrew from blind treatment in both metoprolol- and placebo-treated groups. More metoprolol-treated than placebo-treated patients withdrew because of cardiovascular adverse experience mainly during the very early phase. In all, 45 (6.5%) metoprolol-treated vs 14 (2.0%) placebo-treated patients were not given either a full intravenous dose or a full oral dose 15 minutes later. Bradycardia and hypotension were more common in the metoprolol group, whereas severe atrioventricular block did occur in a similar number of patients in both groups and severe congestive heart failure was more common in the placebo group. Results indicate that tolerance is generally good after intravenous and oral treatment with metoprolol in patients with suspected acute myocardial infarction.
Authors:
J Herlitz; K Pennert; H Wedel; A Vedin; C Wilhelmsson; L Wilhelmsen; A Hjalmarson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  53     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-25     Completed Date:  1984-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46D-50D     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Blood Pressure / drug effects
Clinical Trials as Topic*
Double-Blind Method
Drug Tolerance
Heart Block / etiology
Heart Failure / etiology
Heart Rate / drug effects
Humans
Hypertension / etiology
Injections, Intravenous
Metoprolol / pharmacology,  therapeutic use*
Myocardial Infarction / complications,  drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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