Document Detail

Metoclopramide-induced raised intracranial pressure after head injury.
MedLine Citation:
PMID:  11907399     Owner:  NLM     Status:  MEDLINE    
We report a case of raised intracranial pressure in a head-injured patient following the intravenous administration of metoclopramide. The patient required admission to an intensive care unit after a road traffic accident. A CT scan of the head was consistent with diffuse axonal injury and supportive management included intracranial pressure monitoring. On the third day after admission, intravenous metoclopramide 10mg was administered to aid gastric emptying during nasogastric feeding. Intracranial pressure increased to 39mmHg from a baseline of 15-20mmHg. The same dose of metoclopramide was repeated the next day during transcranial doppler studies with an increase in ICP to 34mmHg and an associated rise in middle cerebral artery systolic blood velocity from 122cms-1 to 150cms-1. This effect of metoclopramide has not been previously reported.
Simon Deehan; Geoffrey J Dobb
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  14     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
Intensive Care Unit, Royal Perth Hospital, Perth, Australia.
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MeSH Terms
Accidents, Traffic
Antiemetics / adverse effects*
Cerebrovascular Circulation / physiology
Craniocerebral Trauma / physiopathology*,  ultrasonography
Glasgow Coma Scale
Intracranial Pressure / drug effects*
Metoclopramide / adverse effects*
Monitoring, Intraoperative
Ultrasonography, Doppler, Transcranial
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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