Document Detail

Metoclopramide-induced impotence and akathisia: a case report.
MedLine Citation:
PMID:  8803308     Owner:  NLM     Status:  MEDLINE    
Metoclopramide (Primperan), a benzamide antiemetic drug, is frequently used in gastrointestinal disorders. Because of its central dopamine antagonist property, it can be a potent stimulant of prolactin release and cause extrapyramidal movement disorders. The case presented is an aged male who developed impotence and akathisia after long-term use of metoclopramide. Akathisia disappeared within 24 hours after withdrawal of metoclopramide. One month after cessation of this drug, his sexual function returned to normal and, in the subsequent five months, he continued to have normal erection. Prolactin level mildly elevated during metoclopramide treatment. It decreased a little two weeks after stopping metoclopramide but elevated again two months later. The characters of these adverse effects of metoclopramide and the prolactin levels of long-term metoclopramide treatment will be discussed. Since metoclopramide is widely used in patients with gastric problems and in cancer patients as antiemetic. It is suggested that long-term use of metoclopramide should be avoided and patients should be carefully observed for potential adverse effects.
S J Tsai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed     Volume:  57     ISSN:  0578-1337     ISO Abbreviation:  Zhonghua Yi Xue Za Zhi (Taipei)     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0005327     Medline TA:  Zhonghua Yi Xue Za Zhi (Taipei)     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, R.O.C.
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MeSH Terms
Akathisia, Drug-Induced / etiology*
Antiemetics / adverse effects*
Erectile Dysfunction / chemically induced*
Metoclopramide / adverse effects*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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