Document Detail

Metoclopramide in gastrooesophageal reflux.
MedLine Citation:
PMID:  4706908     Owner:  NLM     Status:  MEDLINE    
In 30 patients with gastrooesophageal reflux, intravenous metoclopramide (Maxolon) has been shown to increase the gastrooesophageal sphincter pressure. The rise is dose-related until a maximum pressure, proportional to the resting sphincter tone, is reached. The effect is reversed by atropine. Peristaltic waves are increased in pressure by metoclopramide.In 18 patients with gastrooesophageal reflux intravenous metoclopramide diminished the frequency of reflux episodes and increased the rate at which the oesophagus emptied itself of an acid load.
C Stanciu; J R Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  14     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1973 Apr 
Date Detail:
Created Date:  1973-07-24     Completed Date:  1973-07-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  AIM; IM    
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MeSH Terms
Amides / antagonists & inhibitors,  therapeutic use
Anisoles / antagonists & inhibitors,  therapeutic use
Atropine / pharmacology
Benzoates / antagonists & inhibitors,  therapeutic use*
Dose-Response Relationship, Drug
Esophagus / physiopathology
Ethylamines / antagonists & inhibitors,  therapeutic use
Gastroesophageal Reflux / prevention & control*
Hydrogen-Ion Concentration
Injections, Intravenous
Middle Aged
Stomach / physiopathology
Reg. No./Substance:
0/Amides; 0/Anisoles; 0/Benzoates; 0/Ethylamines; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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