| Metoclopramide and domperidone block the antihypertensive effect of bromocriptine in hypertensive patients. | |
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MedLine Citation:
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PMID: 10099042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted in normotensive and hypertensive subjects at the Vargas Hospital of Caracas. Normotensive subjects received, in a cross-over fashion, placebo, metoclopramide (MTC), or domperidone (DOMP), 40 mg of each drug, daily for 1 week. The first group of patients under placebo for 1 week received a single 2.5-mg oral dose of bromocriptine (Br). The second group of patients received 30 mg MTC daily (divided into three doses) for 1 week. At the end of the period a single dose of 2.5 mg Br was administered to each patient. The third group of eight hypertensive patients received DOMP for 1 week at 30 mg/d and then a single 2.5-mg Br dose. Cardiovascular and biochemical parameters including arterial pressure, heart rate, plasma renin activity, and plasma aldosterone were evaluated during the 6-hour period before and after the administration of Br. Neither DOMP nor MTC significantly modified blood pressure and heart rate in normotensive patients. Br reduced both systolic and diastolic arterial pressure in hypertensive subjects. The peak of the antihypertensive effect appeared 3 hours after drug administration, but reduction of arterial pressure lasted approximately 6 hours. At the same time, Br reduced plasma aldosterone levels and plasma renin activity. MTC and DOMP reversed the antihypertensive effect of Br and its effect on aldosterone levels and plasma renin activity. We conclude from these findings that Br acts as an antihypertensive agent at peripheral and central levels by stimulating dopamine-2 receptors, which are involved in the aldosterone and renin secretion. |
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Authors:
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A Luchsinger; M Grilli; M Velasco |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of therapeutics Volume: 5 ISSN: 1075-2765 ISO Abbreviation: Am J Ther Publication Date: 1998 Mar |
Date Detail:
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Created Date: 2000-01-31 Completed Date: 2000-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-8 Citation Subset: IM |
Affiliation:
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Address for correspondence: Apartado Postal 76333, El Marqués, Caracas 1070A, Caracas, Venezuela. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Bromocriptine / antagonists & inhibitors*, pharmacology* Case-Control Studies Cross-Over Studies Domperidone / pharmacology* Dopamine Agonists / pharmacology* Dopamine Antagonists / pharmacology* Drug Antagonism Drug Therapy, Combination Female Humans Hypertension / blood, drug therapy*, physiopathology Male Metoclopramide / pharmacology* Middle Aged Receptors, Dopamine D2 / agonists* Renin / blood, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Dopamine Agonists; 0/Dopamine Antagonists; 0/Receptors, Dopamine D2; 25614-03-3/Bromocriptine; 364-62-5/Metoclopramide; 52-39-1/Aldosterone; 57808-66-9/Domperidone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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