Document Detail

Metoclopramide-induced encephalopathy in Parkinson disease.
MedLine Citation:
PMID:  20065895     Owner:  NLM     Status:  MEDLINE    
A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described. Parkinson disease (PD) is the second most common neurodegenerative disease in the United States. Because of the increased susceptibility to adverse drug effects, PD presents a special challenge to physicians. Anti-emetic drugs such as metoclopramide are widely used and may be particularly deleterious to PD patients due to blockade of dopamine receptors.
Bradley J Robottom; Lisa M Shulman; Karen E Anderson; William J Weiner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  103     ISSN:  1541-8243     ISO Abbreviation:  South. Med. J.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-80     Citation Subset:  AIM; IM    
Departments of Neurology and Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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MeSH Terms
Antiemetics / adverse effects*,  therapeutic use
Constipation / complications,  drug therapy
Metoclopramide / adverse effects*,  therapeutic use
Neurotoxicity Syndromes / complications,  etiology*
Parkinson Disease / complications
Parkinson Disease, Secondary / chemically induced*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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