Document Detail

Methysergide-induced valvular heart disease: a report of 2 cases.
MedLine Citation:
PMID:  17099974     Owner:  NLM     Status:  MEDLINE    
Methysergide is a serotonin antagonist and is used as a long-term prophylactic treatment for migraine. Although many patients experience adequate control of migraine episodes, methysergide has been reported to cause retroperitoneal and pleuropulmonary fibrosis. Cardiovascular side effects mainly in the form of valvular fibrosis have been less recognized. We report 2 cases of methysergide-related mitral valve fibrosis.
Ali M Alizzi; Ayman H Al-Masri; Mark M Murton; Anand S Dixit; Jonathan M Hemli; Michael Challis; Tuck Yong; Michael R Nicholson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The heart surgery forum     Volume:  9     ISSN:  1522-6662     ISO Abbreviation:  Heart Surg Forum     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-13     Completed Date:  2007-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891112     Medline TA:  Heart Surg Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E792-3     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Royal Hobart Hospital, Hobart, Tasmania, Australia.
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MeSH Terms
Heart Valve Diseases / chemically induced*,  surgery
Heart Valve Prosthesis Implantation
Methysergide / adverse effects*
Middle Aged
Mitral Valve / pathology
Serotonin Antagonists / adverse effects*
Reg. No./Substance:
0/Serotonin Antagonists; 361-37-5/Methysergide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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