Document Detail

Methysergide (Sansert) treatment in acute stroke. Community pilot study.
MedLine Citation:
PMID:  3896038     Owner:  NLM     Status:  MEDLINE    
Since its first discovery in 1948, serotonin (5-HT) has been the subject of considerable interest. Its potent vasoactivity led to the hypothesis that altered serotonin metabolism was responsible for the pathophysiology of cerebrovascular disease (infarction & hemorrhage) with documentation of elevated levels of serotonin in CSF. If (5-HT) serotonin-mediated release is ultimately responsible for cerebral edema, vasospasm and infarction in experimental and human stroke, then an opportunity exists to pharmacologically block these effects with serotonin-antagonizing agents. This hypothesis has been tested in the laboratory with several agents that inhibit biogenic amines resulting in promising data suggesting a reduction in damage and disability. Since the "natural history of human stroke" results in a 30-40% mortality within the first three weeks, an aggressive new attempt should be directed to increasing the number of survivors in this initial period of high risk. In this regard Sansert (methysergide) was considered worthy of clinical trials.
M I Weintraub
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  36     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-09-11     Completed Date:  1985-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Brain / radiography
Cerebrovascular Disorders / blood,  drug therapy*,  radiography
Clinical Trials as Topic
Double-Blind Method
Methysergide / therapeutic use*
Middle Aged
Random Allocation
Serotonin / blood
Reg. No./Substance:
361-37-5/Methysergide; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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