Document Detail


Methylxanthines in apnea of prematurity.
MedLine Citation:
PMID:  383366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Caffeine and theophylline are effective in the treatment of apnea in the newborn infant. Controlled studies of efficacy and comparative efficacy and studies of toxicity are visibly lacking. Both drugs exert their anti-apneic activity by stimulation of the respiratory center. Both drugs are eliminated from the baby slowly (caffeine even slower than theophylline) and doses should be adjusted accordingly. Neonates excrete caffeine largely unchanged and they methylate theophylline to caffeine significantly. Caffeine seems preferable to theophylline because of its wider therapeutic index, ease of administration (i.e., given once per day), lesser fluctuation in plasma concentration owing to longer half-life, potent central respirogenic effect, and fewer peripheral side effects. Areas of concern and feasible research have been discussed.
Authors:
J V Aranda; T Turmen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  6     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-108     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Apnea / drug therapy*,  metabolism
Caffeine / administration & dosage,  adverse effects,  metabolism,  pharmacology*,  therapeutic use
Hemodynamics / drug effects
Humans
Infant, Newborn
Infant, Premature, Diseases / drug therapy*,  metabolism
Kinetics
Respiration / drug effects
Theophylline / administration & dosage,  adverse effects,  metabolism,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
58-08-2/Caffeine; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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