Document Detail

Methyltetrahydrophthalic acid in urine as an indicator of occupational exposure to methyltetrahydrophthalic anhydride.
MedLine Citation:
PMID:  15889302     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether methyltetrahydrophthalic acid (MTHP acid) in urine can be used as a biomarker for exposure to methyltetrahydrophthalic anhydride (MTHPA). METHODS: Workers occupationally exposed to MTHPA were studied in combination with one of the authors, who was experimentally exposed to MTHPA. Air levels of MTHPA were determined by personal sampling in the breathing zone. The MTHPA in air was sampled by silica gel and analyzed by gas chromatography (GC) with electron-capture detection. Urinary levels of MTHP acid, a metabolite of MTHPA, were determined in 15 subjects in total. Urine was collected from 14 workers immediately before the start of the work shift and then after 4 and 8 h, and from one of the authors at intervals during 24 h. MTHP acid in urine was analyzed by GC with mass spectrometric detection. RESULTS: The time-weighted average (TWA) air levels ranged from 1.0 microg to 200 microg MTHPA/m3 during 8 h work shifts. The urinary levels of MTHP acid increased during exposure and decayed after the end of exposure, with an estimated half-time of about 3 h. A close correlation was found between the TWA air levels of MTHPA and creatinine-adjusted MTHP acid levels in urine collected at the end of the shift (r = 0.955; P < 0.0001). The current occupational exposure limit of 50 microg MTHPA/m3 (Japan Society for Occupational Health) corresponded to about 1300 microg MTHP acid/g creatinine, which was equivalent to about 900 nmol/mmol creatinine in the International System of Units (SI). CONCLUSIONS: These results indicate that the determination of MTHP acid in urine is suitable for use in the biological monitoring of MTHPA exposure.
Kozo Yokota; Yasushi Johyama; Yukihiro Kunitani; Hiromi Michitsuji; Seiji Yamada
Publication Detail:
Type:  Journal Article     Date:  2005-05-12
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  78     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  IM    
Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, Kadoma, Osaka, 571-0045, Japan.
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MeSH Terms
Data Collection
Environmental Monitoring
Middle Aged
Occupational Exposure*
Phthalic Acids / urine*
Phthalic Anhydrides*
Reg. No./Substance:
0/Phthalic Acids; 0/Phthalic Anhydrides; 26590-20-5/methyltetrahydrophthalic anhydride; 27636-35-7/methyltetrahydrophthalic acid

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