| Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty. | |
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MedLine Citation:
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PMID: 21054459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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WHAT IS KNOWN AND OBJECTIVE: Total knee and hip joint replacement has a high risk of postoperative nausea and vomiting (PONV), and steroid cover is used for cases associated with autoimmune diseases. Our aim is to evaluate the antiemetic efficacy of methylprednisolone as steroid cover in patients undergoing the surgery. METHODS: A prospective cohort study design was used. Sixty-eight patients, aged between 20 and 80 years, were scheduled for a standardized general anaesthetic technique. Patients who were given methylprednisolone were assigned as the steroid cover group, and those who were not given methylprednisolone formed the non-steroid cover group. PONV were assessment by direct questioning or spontaneous complaints by patients 1 week after surgery. Postoperative pain was evaluated using Visual Analog Scale (VAS) 1 and 3 days after surgery. RESULTS AND DISCUSSION: The incidence of nausea in the steroid cover group was significantly less than that in the non-steroid cover group (adjusted odds ratio, 0·17, P = 0·021), but there was no significant difference in vomiting between the two groups. Postoperative pain VAS score was not significantly different between groups. WHAT IS NEW AND CONCLUSION: In total knee and hip arthroplasty, methylprednisolone is effective in preventing postoperative nausea; however, higher doses of methylprednisolone may be needed to prevent vomiting. |
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Authors:
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Y Miyagawa; M Ejiri; T Kuzuya; T Osada; N Ishiguro; K Yamada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 35 ISSN: 1365-2710 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-05-17 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
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Languages: eng Pagination: 679-84 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Department of Hospital Pharmacy, Nagoya University Hospital, Showa-ku, Nagoya, Japan. y-miyaga@med.nagoya-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antiemetics / therapeutic use* Arthroplasty, Replacement, Hip* Arthroplasty, Replacement, Knee* Female Humans Male Methylprednisolone / therapeutic use* Metoclopramide / therapeutic use Middle Aged Pain Measurement Pain, Postoperative / drug therapy Postoperative Nausea and Vomiting / drug therapy* Vomiting / drug therapy* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 364-62-5/Metoclopramide; 83-43-2/Methylprednisolone |
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