Document Detail

Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty.
MedLine Citation:
PMID:  21054459     Owner:  NLM     Status:  MEDLINE    
WHAT IS KNOWN AND OBJECTIVE: Total knee and hip joint replacement has a high risk of postoperative nausea and vomiting (PONV), and steroid cover is used for cases associated with autoimmune diseases. Our aim is to evaluate the antiemetic efficacy of methylprednisolone as steroid cover in patients undergoing the surgery.
METHODS: A prospective cohort study design was used. Sixty-eight patients, aged between 20 and 80 years, were scheduled for a standardized general anaesthetic technique. Patients who were given methylprednisolone were assigned as the steroid cover group, and those who were not given methylprednisolone formed the non-steroid cover group. PONV were assessment by direct questioning or spontaneous complaints by patients 1 week after surgery. Postoperative pain was evaluated using Visual Analog Scale (VAS) 1 and 3 days after surgery.
RESULTS AND DISCUSSION: The incidence of nausea in the steroid cover group was significantly less than that in the non-steroid cover group (adjusted odds ratio, 0·17, P = 0·021), but there was no significant difference in vomiting between the two groups. Postoperative pain VAS score was not significantly different between groups.
WHAT IS NEW AND CONCLUSION: In total knee and hip arthroplasty, methylprednisolone is effective in preventing postoperative nausea; however, higher doses of methylprednisolone may be needed to prevent vomiting.
Y Miyagawa; M Ejiri; T Kuzuya; T Osada; N Ishiguro; K Yamada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  35     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-05-17     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Department of Hospital Pharmacy, Nagoya University Hospital, Showa-ku, Nagoya, Japan.
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MeSH Terms
Aged, 80 and over
Antiemetics / therapeutic use*
Arthroplasty, Replacement, Hip*
Arthroplasty, Replacement, Knee*
Methylprednisolone / therapeutic use*
Metoclopramide / therapeutic use
Middle Aged
Pain Measurement
Pain, Postoperative / drug therapy
Postoperative Nausea and Vomiting / drug therapy*
Vomiting / drug therapy*
Young Adult
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 83-43-2/Methylprednisolone

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