Document Detail

Methylprednisolone has a preventive effect on the development of radiological changes, thickening and stiffening of the rabbit knee following immobilization.
MedLine Citation:
PMID:  2261704     Owner:  NLM     Status:  MEDLINE    
The effect of methylprednisolone (MP), Depo-Medrol, on the development of radiologically detectable changes, i.e. thickening and stiffening in rabbit knees following a standard immobilization method, was investigated. The right knees of 34 rabbits were immobilized by a splint and an elastic bandage in extension for five weeks, whereafter the splint was removed. Twelve of the rabbits were given MP in the back muscles once a week during the immobilization period only and eight other rabbits were given diminishing doses during the immobilization period and also during the remobilization period. Marked radiologically detectable changes, stiffening, and thickening developed regularly in the immobilized knees of the rabbits which were not given MP. In the other rabbits MP had a significant preventive effect on the development of all these pathological signs. The degree of the effect of MP was related to the dose and to the administration period. The optimal effect was registered when MP was given initially in large but then gradually diminishing doses during the immobilization and the remobilization periods.
J E Michelsson; S Juntunen; T Valtakari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  8     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-02-01     Completed Date:  1991-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  IM; S    
Helsinki University Central Hospital, Department of Orthopaedics and Traumatology, Finland.
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MeSH Terms
Arthritis / prevention & control*
Dose-Response Relationship, Drug
Knee Joint / drug effects*,  physiopathology,  radiography
Methylprednisolone / pharmacology*
Movement / drug effects
Reg. No./Substance:

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