| Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery. | |
| | |
MedLine Citation:
|
PMID: 22939108 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. METHODS: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO(2)/FiO(2) coefficient, and microalbuminuria. RESULTS: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO(2)/FiO(2) was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. CONCLUSION: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass. |
| | |
Authors:
|
Vladimir V Lomivorotov; Sergey M Efremov; Andrey P Kalinichenko; Igor A Kornilov; Lubov G Knazkova; Alexandr M Chernyavskiy; Vladimir N Lomivorotov; Alexander M Karaskov |
Related Documents
:
|
14666008 - Home surveillance program prevents interstage mortality after the norwood procedure. 9568628 - Pulmonary arteriovenous fistula: long-term results of percutaneous transcatheter emboli... 18499588 - Transdermal oxygen does not improve sternal wound oxygenation in patients recovering fr... 19117168 - Surgical intervention represents a feasible option for patients with mild obstructive s... 7577638 - Results of long-term deferiprone (l1) therapy: a report by the international study grou... 18239868 - Conservative management of hemorrhoids: a comparison of venotonic flavonoid micronized ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-28 |
Journal Detail:
|
Title: Heart, lung & circulation Volume: - ISSN: 1444-2892 ISO Abbreviation: Heart Lung Circ Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-9-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100963739 Medline TA: Heart Lung Circ Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Axial rotation of the first metatarsal head in a normal population and hallux valgus patients.
Next Document: The Role of the Preoperative Screening of Sleep Apnoea by Berlin Questionnaire and Epworth Sleepines...