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Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery.
MedLine Citation:
PMID:  22939108     Owner:  NLM     Status:  Publisher    
BACKGROUND: The objective of this study was to investigate the effect of the perioperative use of methylprednisolone in medium doses on markers of endothelial cell activation in patients with coronary artery disease undergoing cardiopulmonary bypass. METHODS: In this prospective, double-blinded, placebo-controlled, randomised study, 44 patients, undergoing a coronary artery bypass graft surgery received either methylprednisolone 20mg/kg or a placebo intraoperatively after anaesthesia induction. The primary endpoint was endothelin-1, and secondary endpoints were E-selectin, interleukin (IL)-6 and IL-10, PaO(2)/FiO(2) coefficient, and microalbuminuria. RESULTS: Endothelin-1 was higher in the study group postoperatively at 10min (p=0.0008), 2h (p=0.02), 4h (p=0.005), and 24h (p=0.004). IL-6 was lower in the study group postoperatively at 2h (p=0.03), 4h (p=0.04), and 24h (p<0.0001). IL-10 was higher in the study group postoperatively at 10min (p<0.0001), 2h (p=0.009), and 4h (p=0.001). PaO(2)/FiO(2) was lower in the study group at 24h after surgery (p=0.03). Microalbuminuria was similar in both groups. CONCLUSION: Despite an obvious anti-inflammatory effect, methylprednisolone causes endothelial cell activation in patients undergoing cardiopulmonary bypass.
Vladimir V Lomivorotov; Sergey M Efremov; Andrey P Kalinichenko; Igor A Kornilov; Lubov G Knazkova; Alexandr M Chernyavskiy; Vladimir N Lomivorotov; Alexander M Karaskov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-28
Journal Detail:
Title:  Heart, lung & circulation     Volume:  -     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
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