Document Detail

Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.
MedLine Citation:
PMID:  12907924     Owner:  NLM     Status:  MEDLINE    
An 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminished over several weeks when methylphenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder. It appears that methylphenidate precipitated the patient's pathological behavior.
Michael Serby
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  CNS spectrums     Volume:  8     ISSN:  1092-8529     ISO Abbreviation:  CNS Spectr     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2003-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9702877     Medline TA:  CNS Spectr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-3     Citation Subset:  IM    
Department of Psychiatry, Beth Israel Medical Center, and Albert Einstein College of Medicine, New York, New York 10003, USA.
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MeSH Terms
Aged, 80 and over
Anti-Anxiety Agents / administration & dosage
Antidepressive Agents, Second-Generation / administration & dosage
Anxiety Disorders / diagnosis,  drug therapy
Buspirone / administration & dosage
Central Nervous System Stimulants / administration & dosage,  adverse effects*
Depressive Disorder / drug therapy*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Fluvoxamine / administration & dosage
Follow-Up Studies
Methylphenidate / administration & dosage,  adverse effects*
Obsessive-Compulsive Disorder / chemically induced*,  diagnosis,  drug therapy
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidepressive Agents, Second-Generation; 0/Central Nervous System Stimulants; 113-45-1/Methylphenidate; 36505-84-7/Buspirone; 54739-18-3/Fluvoxamine

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