Document Detail

Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.
MedLine Citation:
PMID:  18431096     Owner:  NLM     Status:  MEDLINE    
Methylphenidate and dextroamphetamine are central nervous system stimulants used in the treatment of attention deficit hyperactivity disorders in children. These medications have been associated with cerebral arteritis, renal necrotizing vasculitis, and systemic and pulmonary hypertension. We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon. Two patients were found to have a positive ANA at low titers, 1 of whom had histopathologic evidence of stratum malgiphian necrosis with perivascular lymphocytic infiltration on skin biopsy. Two had positive antihistone antibodies. One patient improved after withdrawal of dextroamphetamine; others had worsening of their symptoms on higher doses of medications. These cases indicate the potential for development of acral cyanosis, livedo reticularis, or Raynaud symptoms with these medications and their potential contribution to a vasculopathy.
Reema H Syed; Terry L Moore
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  14     ISSN:  1536-7355     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-04-23     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-3     Citation Subset:  IM    
Division of Rheumatology, Saint Louis University Medical Center, Saint Louis, Missouri 63104, USA.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / drug therapy
Central Nervous System Stimulants / adverse effects*
Dextroamphetamine / adverse effects*
Livedo Reticularis / chemically induced*
Methylphenidate / adverse effects*
Peripheral Vascular Diseases / chemically induced*
Raynaud Disease / chemically induced*
Reg. No./Substance:
0/Central Nervous System Stimulants; 113-45-1/Methylphenidate; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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