Document Detail


Methylmethacrylate metabolism in man. The hydrolysis of methylmethacrylate to methacrylic acid during total hip replacement.
MedLine Citation:
PMID:  477128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methylmethacrylate, the monomeric component of the polymethylmethacrylate cement used in orthopedic surgery, has been shown to undergo hydrolysis to methacrylic acid during hip replacement operations. Circulating levels of methacrylic acid were comparable with those of methylmethacrylate. Concentrations of both methylmethacrylate and methacrylic acid normally lay in the range 0--15 micrograms/cc. No correlation could be discerned between changes in the concentrations of methylmethacrylate and methacrylic acid, and changes in blood pressure.
Authors:
D H Crout; J A Corkill; M L James; R S Ling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetabulum / metabolism
Acrylic Resins / metabolism*
Adult
Aged
Blood Pressure
Female
Femur / metabolism
Hip Prosthesis*
Humans
Male
Methacrylates / blood,  urine
Middle Aged
Polymethacrylic Acids / metabolism*,  therapeutic use
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/Methacrylates; 0/Polymethacrylic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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