Document Detail


Methylmercury exposure and reproductive dysfunction in the nonhuman primate.
MedLine Citation:
PMID:  6464019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Macaca fascicularis females were monitored daily through four menstrual cycles then orally administered 0, 50, or 90 micrograms/kg/day methylmercury hydroxide (MeHg). Females were monitored through four additional menstrual cycles and after approximately 124 days of MeHg treatment were time-mated to nontreated males. MeHg treatment did not affect menstrual cycle or menses length. The relationship between dosage of MeHg and reproductive outcome approached but did not reach statistical significance. Reproductive failure (i.e., nonconception, abortion) was, however, related to a significantly higher blood Hg concentration than reproductive success for MeHg-treated females. The offspring of MeHg-treated females tended to be smaller than control infants, but no statistically significant decrease in gestation, birthweight, or crown-rump length was observed. None of the females receiving MeHg exhibited signs of MeHg toxicity during breeding or pregnancy. Daily treatment with 90 micrograms/kg/day MeHg for nearly 1 year, however, produced signs of toxicity in four of seven females. Toxicity was related to increased maternal size, duration of MeHg treatment, and a blood Hg concentration of 2.3 to 2.8 ppm.
Authors:
T M Burbacher; C Monnett; K S Grant; N K Mottet
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  75     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-13     Completed Date:  1984-09-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / blood
Birth Weight / drug effects
Body Weight / drug effects
Female
Fertilization / drug effects
Macaca fascicularis
Male
Maternal-Fetal Exchange
Menstruation / drug effects
Methylmercury Compounds / blood,  toxicity*
Pregnancy
Reproduction / drug effects*
Grant Support
ID/Acronym/Agency:
ES 00677/ES/NIEHS NIH HHS; T32 ES 07032/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Methylmercury Compounds; 1184-57-2/methylmercury hydroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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