Document Detail

Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals.
MedLine Citation:
PMID:  2196419     Owner:  NLM     Status:  MEDLINE    
A qualitative and quantitative comparison of the neuropathological and neurobehavioral effects of early methylmercury (MeHg) exposure is presented. The focus of the qualitative comparison is the examination of how specific end-points (and categories of behavioral functions) compare across species. The focus of the quantitative comparison is the investigation of the relationship between MeHg exposure, target-organ dose and effects in humans and animals. The results of the comparisons are discussed in the context of the adequacy of the proposed EPA neurotoxicity battery to characterize the risk of MeHg to humans. The comparisons reveal several qualitative and quantitative similarities in the neuropathological effects of MeHg on humans and animals at high levels of exposure. Reports of neuropathological effects at lower levels are available for animals only, precluding any comparison. At high levels of exposure, specific neurobehavioral end-points affected across species are also similar. Effects at lower levels of exposure are similar if categories of neurobehavioral functioning are compared. Changes in the EPA test battery consistent with the results of the comparisons are discussed.
T M Burbacher; P M Rodier; B Weiss
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  12     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1990 May-Jun
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-202     Citation Subset:  IM    
Department of Environmental Health, University of Washington, Seattle 98195.
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MeSH Terms
Behavior / drug effects
Behavior, Animal / drug effects
Dose-Response Relationship, Drug
Methylmercury Compounds / toxicity*
Nervous System Diseases / chemically induced*,  pathology
Prenatal Exposure Delayed Effects*
Species Specificity
Grant Support
Reg. No./Substance:
0/Methylmercury Compounds; 0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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