| Methylglyoxal content in drinking coffee as a cytotoxic factor. | |
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MedLine Citation:
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PMID: 20722928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A causal relationship between metabolic syndrome and methylglyoxal (MG) has been suggested. Consumption of coffee and other types of beverages has been known to produce MG, thus resulting in both nutritional and health concerns. The purpose of this study was to determine the ideal combination of coffee, cream, and sugar in order to minimize MG consumption. Four types of black coffee were tested: espresso, bold, mild, and a decaffeinated mild roast. Sugar and/or cream were added to the coffee samples to test whether MG levels were altered. Using high-performance liquid chromatography, the concentration of MG in various coffee samples was determined. The espresso coffee sample was found to contain the highest level of MG at 230.9 microM. The bold coffee roast had the 2nd highest amount of MG, followed by the mild and decaffeinated varieties. Adding cream to bold coffee significantly reduced its MG level in comparison to the coffee sample without cream. On the other hand, the addition of sugar to the bold coffee did not further increase the MG level in the samples. The cellular damaging effect of MG was shown as there were decreased numbers of cultured HEK-293 cells after 24 h of MG treatment (100 and 300 microM), which is consistent with an increased cell apoptosis induced by MG treatment (100 and 300 microM). Due to the overconsumption of exogenous MG, drinking an excess of any type of coffee poses health risks. |
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Authors:
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J Wang; T Chang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of food science Volume: 75 ISSN: 1750-3841 ISO Abbreviation: J. Food Sci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: United States |
Other Details:
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Languages: eng Pagination: H167-71 Citation Subset: IM |
Affiliation:
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Walter Murray Collegiate Inst., Saskatoon, SK, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Caffeine / chemistry Cell Proliferation / drug effects Chromatography, High Pressure Liquid Coffee / adverse effects*, chemistry* Cytostatic Agents / analysis, chemistry, toxicity Cytotoxins / analysis, chemistry, toxicity* Dietary Sucrose / chemistry Food Handling HEK293 Cells Humans Metabolic Syndrome X / epidemiology Milk / chemistry Osmolar Concentration Pyruvaldehyde / analysis, chemistry, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Coffee; 0/Cytostatic Agents; 0/Cytotoxins; 0/Dietary Sucrose; 58-08-2/Caffeine; 78-98-8/Pyruvaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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