| Methylglyoxal Accumulation in Arterial Walls Causes Vascular Contractile Dysfunction in Spontaneously Hypertensive Rats. | |
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MedLine Citation:
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PMID: 22971844 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Methylglyoxal (MGO) is a metabolite of glucose and perhaps mediates diabetes-related macrovascular complications including hypertension. In the present study, we examined if MGO accumulation affects vascular reactivity of isolated mesenteric artery from spontaneously hypertensive rats (SHR). Five-week-old SHR were treated with an MGO scavenger, aminoguanidine (AG), for 5 weeks. AG partially normalized increased blood pressure in SHR. In mesenteric artery from SHR treated with AG, increased accumulation of MGO-derived advanced glycation end-products was reversed. In mesenteric artery from SHR, AG normalized impaired acetylcholine (ACh)-induced relaxation and increased angiotensin (Ang) II-induced contraction. Reactive oxygen species (ROS) production increased in SHR mesenteric artery, and acute treatment with a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor augmented ACh-induced relaxation. Protein expression of NOX1 and Ang II type 2 receptor (AT2R) increased in SHR mesenteric artery, which was normalized by AG. Acute treatment with an AT2R blocker but not a NOX inhibitor normalized the increased Ang II-induced contraction in SHR mesenteric artery. The present results demonstrate that MGO accumulation in mesenteric artery may mediate development of hypertension in SHR at least in part via increased ROS-mediated impairment of endothelium-dependent relaxation and AT2R-mediated increased Ang II contraction. |
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Authors:
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Masashi Mukohda; Muneyoshi Okada; Yukio Hara; Hideyuki Yamawaki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-23 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: - ISSN: 1347-8648 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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