Document Detail

Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea.
MedLine Citation:
PMID:  15533596     Owner:  NLM     Status:  MEDLINE    
Several, but not all, studies have reported that a variant genotype of the polymorphism (C677T) of 5,10-methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, is associated with a decreased risk of colorectal cancer. A case-control study was conducted to investigate the association of MTHFR polymorphism and heavy alcohol intake to colon and rectal cancer in Korean. Cases were a consecutive series of patients with histologically confirmed, incident colorectal cancer who were admitted to two university hospitals in Seoul, Korea between 1998 and 2000, and controls were selected at the same hospitals. A total of 243 cases (colon 111, rectum 132) and 225 controls were enrolled. While the genotype of MTHFR was not associated with the overall risk of colorectal cancer, increased colon cancer risk was found to be associated with the CT and TT genotypes combined (multivariate odds ratio [OR] 2.01, 95% confidence interval [CI] 1.14-3.53) compared with the wild type. The risk of rectal cancer was found to be, though statistically non-significant, lower in those with the CT and TT genotypes combined (multivariate OR 0.67, 95% CI: 0.43-1.07). Those consuming two or more drinks per day (30 g+/day) had nearly twice the colorectal cancer risk (multivariate OR 1.94, 95% CI 1.03-3.68) of light or non-drinkers (<5 g/day). The present study did not find a reduced risk of colorectal or rectal cancer among those with a variant genotype of the MTHFR polymorphism, but observed rather an increased risk of colon cancer, suggesting that the effects of the MTHFR genotype may differ in populations with different levels of folate intake.
Dong-Hyun Kim; Yoon-Ok Ahn; Bong-Hwa Lee; Emiko Tsuji; Chikako Kiyohara; Suminori Kono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  216     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-09     Completed Date:  2005-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Department of Social and Preventive Medicine, Hallym University College of Medicine, Kangwon-do, South Korea.
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MeSH Terms
Adenocarcinoma / epidemiology,  etiology,  genetics*
Alcohol Drinking / adverse effects,  genetics*
Case-Control Studies
Colonic Neoplasms / epidemiology,  etiology,  genetics*
Gene Frequency
Korea / epidemiology
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Middle Aged
Odds Ratio
Polymorphism, Genetic
Rectal Neoplasms / epidemiology,  etiology,  genetics*
Reg. No./Substance:
EC Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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