Document Detail

Methylenetetrahydrofolate reductase gene polymorphisms in patients with cerebral hemorrhage.
MedLine Citation:
PMID:  15829163     Owner:  NLM     Status:  MEDLINE    
Elevated plasma total homocysteine (HCY) level is a risk factor for coronary heart disease and ischemic stroke. We investigated relationships between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, and plasma levels of HCY and folate in patients of Mongolian races who suffered from cerebral ischemia (CI, n = 42) or cerebral hemorrhage (CH, n = 20) and in the 24 age-matched controls. The incidences of both homozygous and heterozygous MTHFR gene mutations in CI (26 and 43%) and in CH (25 and 60%) were significantly higher than those in the controls (8 and 25%). Homozygous MTHFR gene mutation was associated with reduced plasma folate levels, but not with increased plasma HCY levels. Among the subjects with homozygous MTHFR gene mutation, plasma folate levels in CH was significantly lower than those in CI and controls. MTHFR gene mutation in CH was found to be as common as that in CI and was associated with reduced plasma folate levels in the both. In homozygous MTHFR gene mutation, the plasma folate level was profoundly reduced in CH as compared with CI and controls, suggesting that subjects with low plasma folate levels have a predisposition to intracerebral bleeding.
Xin Fang; Hiroki Namba; Soichi Akamine; Kenji Sugiyama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  27     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-04-14     Completed Date:  2005-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Case-Control Studies
Cerebral Hemorrhage / genetics*
Chi-Square Distribution
DNA Mutational Analysis
Gene Frequency
Genetic Predisposition to Disease*
Methylenetetrahydrofolate Reductase (NADPH2) / blood,  genetics*
Middle Aged
Polymorphism, Genetic*
Pteroylpolyglutamic Acids / blood
RNA, Messenger / biosynthesis
Reverse Transcriptase Polymerase Chain Reaction / methods
Reg. No./Substance:
0/Pteroylpolyglutamic Acids; 0/RNA, Messenger; EC Reductase (NADPH2)

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