Document Detail


Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia.
MedLine Citation:
PMID:  15059157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A methylenetetrahydrofolate reductase (MTHFR) polymorphism (1317T --> C) that occurs commonly in black African individuals prompted this study to establish whether this polymorphism, alone or in association with other MTHFR variants, is associated with preeclampsia in black South African women. METHODS: A group of 204 black women with preeclampsia was examined for the 677C --> T, 1298A --> C and 1317T --> C MTHFR polymorphic alleles using standard techniques. Also examined were women with early-onset preeclampsia (n = 67) and gestational hypertension (n = 78). Results were compared with 338 ethnically matched normotensive pregnant women who had normal full-term gestations. RESULTS: No differences in the 677T --> C or 1298A --> C MTHFR alleles were found between the study groups and controls; very few women were homozygous for either variant allele. Significant differences were observed for the 1317T --> C polymorphism: only 39% of preeclamptics were homozygous for the T allele compared with 52% of the control group [p = 0.002; 0.59 (0.42-0.83)]. Heterozygotes occurred significantly more frequently in preeclamptics (51%), compared with controls (41%) [p = 0.019; 1.49 (1.07-2.08)]. Allele frequencies also differed significantly between preeclamptics and controls [p = 0.003; 0.69 (0.53-0.88)]. Allele frequencies in women with gestational hypertension were statistically indistinguishable from those in controls. CONCLUSION: The low frequencies of the 677C --> T and 1298A --> C MTHFR variant alleles in black South Africans imply little or no role for these mutations in preeclampsia in this population group. However, significant differences in the 1317T --> C allele in preeclamptics suggest that the MTHFR gene, or a closely associated gene, may still have some role, as yet undefined, in the pathogenesis of preeclampsia.
Authors:
Rosemary J Pegoraro; Aggrey Chikosi; Lee Rom; Candice Roberts; Jack Moodley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  449-54     Citation Subset:  IM    
Affiliation:
Department of Chemical Pathology, MRC/UN Pregnancy Hypertension Research Unit, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella 4013, Durban, South Africa. pegoraro@nu.ac.za
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*
Female
Humans
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymorphism, Genetic
Pre-Eclampsia / genetics*
Pregnancy
South Africa
Chemical
Reg. No./Substance:
EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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