| Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults. | |
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MedLine Citation:
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PMID: 21270364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although methylenetetrahydrofolate reductase (MTHFR) genetic variants are associated with plasma homocysteine (Hcy) and cardiovascular disease (CVD), little is known whether dietary fatty acid intake modulates these associations. The goal was to examine the interaction of MTHFR variants with dietary fatty acids influencing plasma Hcy in 995 Boston Puerto Rican adults. We found that plasma Hcy concentration was negatively correlated with (n-3) PUFA intake (r = -0.117; P = 0.022), and the ratio of (n-3):(n-6) PUFA in the diet (r = -0.122; P = 0.009). Further, 2 functional MTHFR variants, 1298A>C and 677C>T, which are not in linkage disequilibrium in this population, were significantly associated with hypertension (OR = 1.72, P = 0.024, and OR = 1.60, P = 0.002, respectively). In addition, the 1298A>C variant was significantly associated with CVD (OR = 3.32; P = 0.030). Importantly, this variant exhibited significant interactions with intakes of total and (n-6) PUFA and the (n-3):(n-6) PUFA ratio of the diet. The plasma Hcy concentration of carriers of risk allele 1298C was greater than that of noncarriers only when participants had consumed a high-PUFA diet (>7.8% energy) but was not greater when they had low intake of PUFA (≤7.8% energy). In addition, participants with combined genotypes of both SNP (677 TT with 1298 AC or CC) who consumed high levels of (n-3) PUFA (>0.66% energy) had lower plasma Hcy compared with those who had the same genotype and consumed low levels of (n-3) PUFA (≤0.66% energy). Our study suggests that dietary PUFA intake modulates the effect of 2 MTHFR variants on plasma Hcy in Boston Puerto Rican adults. |
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Authors:
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Tao Huang; Katherine L Tucker; Yu-Chi Lee; Jimmy W Crott; Laurence D Parnell; Jian Shen; Caren E Smith; Jose M Ordovas; Duo Li; Chao-Qiang Lai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-01-26 |
Journal Detail:
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Title: The Journal of nutrition Volume: 141 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-05-24 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 654-9 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, Zhejiang University, Hangzhou, 310029 China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiovascular Diseases / blood, etiology, genetics* Dietary Fats / administration & dosage* Fatty Acids, Unsaturated / administration & dosage* Female Genotype Homocysteine / blood* Humans Hypertension / blood, etiology, genetics* Male Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Middle Aged Polymorphism, Single Nucleotide |
| Grant Support | |
ID/Acronym/Agency:
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5P01AG023394-02/AG/NIA NIH HHS; HL078885/HL/NHLBI NIH HHS; HL54776/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Unsaturated; 454-28-4/Homocysteine; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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