| Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 22143415 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: A systematic review and a meta-analysis were conducted, to investigate the possible association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms with adverse effects related to methotrexate (MTX). METHODS: A systematic literature search in PubMed retrieved a total of 44 studies (42 unique articles). Two polymorphisms were included in the meta-analysis: C677T and A1298C. Random effect models were used in the analysis. Odds ratios along with their 95% confidence intervals were computed to compare the distribution of alleles and genotypes between cases and controls. RESULTS: The analysis highlighted a significant association of C677T polymorphism with overall MTX toxicity, hepatotoxicity, hematological toxicity, and neurotoxicity. It also revealed an association with MTX toxicity in patients with rheumatoid arthritis. In contrast, a protective effect of C677T MTHFR polymorphism on acute graft-versus-host disease and on patients treated with hematopoietic cell transplantation was found. As for the A1298C polymorphism, a statistically significant association with overall MTX toxicity and a protective role of the polymorphism in rheumatoid arthritis patients was detected. CONCLUSION: These results indicate the association of MTHFR polymorphisms with MTX toxicity. However, further studies are needed to reveal the underlying biological mechanism of the association. |
| | |
Authors:
|
Kalliopi P Spyridopoulou; Niki L Dimou; Stavros J Hamodrakas; Pantelis G Bagos |
Related Documents
:
|
21823095 - Development and testing of 13 polymorphic microsatellite markers in larimichthys polyac... 21637505 - Haptoglobin gene subtypes in three brazilian population groups of different ethnicities. 21603025 - High-resolution melting (hrm) analysis of the cu/zn superoxide dismutase (sod1) gene in... 11243815 - Structure and function of the conserved 690 hairpin in escherichia coli 16 s ribosomal ... 12111645 - A novel polymorphism in exon 11 of the wkl1 gene, shows no association with schizophrenia. 1679985 - Use of dna polymorphisms for genetic analysis of non-insulin dependent diabetes mellitus. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
|
Title: Pharmacogenetics and genomics Volume: - ISSN: 1744-6880 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231005 Medline TA: Pharmacogenet Genomics Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
aDepartment of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens bDepartment of Computer Science and Biomedical Informatics, University of Central Greece, Papasiopoulou, Lamia, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery di...
Next Document: Asymptomatic bacteriuria: when the treatment is worse than the disease.