Document Detail


Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight.
MedLine Citation:
PMID:  22810058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early life experiences, including those in utero, have been linked to increased risk for adult-onset chronic disease. The underlying assumption is that there is a critical period of developmental plasticity in utero when selection of the fetal phenotype that is best adapted to the intrauterine environment occurs. The current study is the first to test the idea that extreme maternal psychosocial stressors, as observed in the Democratic Republic of Congo, may modify locus-specific epigenetic marks in the newborn resulting in altered health outcomes. Here we show a significant correlation between culturally relevant measures of maternal prenatal stress, newborn birth weight and newborn methylation in the promoter of the glucocorticoid receptor NR3C1. Increased methylation may constrain plasticity in subsequent gene expression and restrict the range of stress adaptation responses possible in affected individuals, thus increasing their risk for adult-onset diseases.
Authors:
Connie J Mulligan; Nicole C D'Errico; Jared Stees; David A Hughes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-19
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  7     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-14     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  853-7     Citation Subset:  IM    
Affiliation:
Department of Anthropology, University of Florida, Gainesville, FL, USA. cmulligan@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Birth Weight / genetics*
DNA Methylation / genetics*,  physiology
Democratic Republic of the Congo / epidemiology
Female
Humans
Infant, Newborn
Male
Pregnancy
Prenatal Exposure Delayed Effects / genetics*,  physiopathology
Promoter Regions, Genetic
Receptors, Glucocorticoid / genetics*
Stress, Psychological / epidemiology,  genetics*,  physiopathology
Grant Support
ID/Acronym/Agency:
UL1 TR000064/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/NR3C1 protein, human; 0/Receptors, Glucocorticoid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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