| Methylation analysis of KvDMR1 in human oocytes. | |
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MedLine Citation:
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PMID: 16950814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, several reports have been published that showed a higher incidence of assisted reproductive technologies (ART) in patients with Beckwith-Wiedemann syndrome compared with the general population, and in most of these patients, aberrant methylation imprints of KvDMR1 have been found. This has led to the concern that ART might increase the incidence of imprinting syndromes such as Beckwith-Wiedemann syndrome. Not much is known on environmental or genetic factors that may interfere with the processes of imprint maintenance or resetting. A methylation analysis of KvDMR1 was performed in human oocytes at different stages of nuclear maturity and in sperm cells. The results indicate that the maternal methylation imprints were already established at the germinal vesicle stage, whereas all sperm cells were unmethylated, thereby showing that the KvDMR1 carries a germline methylation imprint. For one of the oocytes analysed, an unmethylated pattern was found, which highlights the need for further molecular studies that consider the safety of ART. |
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Authors:
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Elke Geuns; Pierre Hilven; André Van Steirteghem; Inge Liebaers; Martine De Rycke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-01 |
Journal Detail:
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Title: Journal of medical genetics Volume: 44 ISSN: 1468-6244 ISO Abbreviation: J. Med. Genet. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-12 Completed Date: 2007-06-07 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 2985087R Medline TA: J Med Genet Country: England |
Other Details:
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Languages: eng Pagination: 144-7 Citation Subset: IM |
Affiliation:
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Research Centre Reproduction and Genetics, Academisch Ziekenhuis Vrije Universiteit Brussel, Laarbeeklaan, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Beckwith-Wiedemann Syndrome / genetics DNA / blood, genetics, isolation & purification DNA Methylation Female Humans Membrane Proteins / genetics* Oocytes / physiology* Potassium Channels, Voltage-Gated / genetics Sperm Injections, Intracytoplasmic |
| Chemical | |
Reg. No./Substance:
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0/KCNQ1OT1 protein, human; 0/Membrane Proteins; 0/Potassium Channels, Voltage-Gated; 9007-49-2/DNA |
| Comments/Corrections | |
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