Document Detail


Methylated arginine derivatives in children and adolescents with chronic kidney disease.
MedLine Citation:
PMID:  18830716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asymmetric dimethylarginine (ADMA), a methylated L: -arginine (Arg) derivative is associated with endothelial dysfunction, vasoconstriction, and hypertension in animals and humans. We examined the relationship between these derivatives, estimated glomerular filtration rate (eGFR), and awake (AW) and asleep (AS) blood pressure (BP) load in children and adolescents (n = 28) with stage 2-3 chronic kidney disease (CKD) and in matched intra-familial controls (n = 10). Plasma L: -Arg, ADMA, and symmetric dimethylarginine (SDMA) levels were measured by high-performance liquid chromatography-tandem mass spectrometry. Subjects wore a 24-hr ambulatory BP monitor with BP load >95th percentile. ADMA, SDMA/ADMA ratio and SDMA were 38-200% higher in CKD patients while L: -Arg/ADMA and L: -Arg/SDMA ratios and the L: -Arg level were 11-64% lower. The eGFR explained 42-60% of L: -Arg/SDMA, SDMA/ADMA, and SDMA variability (n = 38). Using linear regression, SDMA and SDMA/ADMA separately explained 15-38% of AW and AS systolic (S) BP and diastolic (D) BP load variability (p < 0.001-0.022). Using multivariate stepwise regression with eGFR held constant, SDMA/ADMA was a significant independent variable for AW DBP load (p = 0.03). In conclusion, BP load and a disproportionate elevation of SDMA are seen in children and adolescents with stage 2-3 (mild-moderate) CKD. SDMA is a strong marker for reduced eGFR and serves as a moderate but significant indicator of 24-hr BP load variability.
Authors:
Ellen R Brooks; Craig B Langman; Sihe Wang; Heather E Price; Abigail L Hodges; Lara Darling; Amy Z Yang; Frederick A Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-02
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  24     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Kidney Diseases, Children's Memorial Hospital and Northwestern University Feinberg Medical School, Chicago, IL, USA. e-brooks3@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Arginine / analogs & derivatives*,  blood
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Child
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Female
Food Deprivation
Glomerular Filtration Rate
Humans
Hypertension / blood,  etiology,  physiopathology
Male
Renal Insufficiency, Chronic / blood*,  complications,  physiopathology
Tandem Mass Spectrometry
Grant Support
ID/Acronym/Agency:
M01 RR-00048/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/dimethylarginine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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