| [(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 20401538 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: Studies have established the value of [(methyl)1-(11)C]-acetate ([(11)C]Act) combined with 2-deoxy-2[(18)F]fluoro-D: -glucose (FDG) for detecting hepatocellular carcinoma (HCC) using positron emission tomography (PET). In this study, the metabolic fate of [(11)C]Act in HCC was characterized. METHODS: Experiments with acetic acid [1-(14)C] sodium salt ([(14)C]Act) were carried out on WCH-17 cells and freshly derived rat hepatocytes. PET scans with [(11)C]Act were also carried out on woodchucks with HCC before injection of [(14)C]Act. The radioactivity levels in different metabolites were quantified with thin-layer chromatography. RESULTS: In WCH-17 cells, the predominant metabolite was phosphatidylcholine (PC). Regions of HCCs with the highest [(11)C]Act uptake had higher radioactivity accumulation in lipid-soluble compounds than surrounding hepatic tissues. In those regions, PC and triacylglycerol (TG) accumulated more radioactivity than in surrounding hepatic tissues. CONCLUSIONS: High [(11)C]Act uptake in HCC is associated with increased de novo lipogenesis. PC and TG are the main metabolites into which the radioactive label from [(11)C]Act is incorporated in HCC. |
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Authors:
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Nicolas Salem; Yu Kuang; David Corn; Bernadette Erokwu; Jeffrey A Kolthammer; Haibin Tian; Chunying Wu; Fangjing Wang; Yanming Wang; Zhenghong Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 13 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 140-51 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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