Document Detail

Methyl palmitate prevents CCl(4)-induced liver fibrosis.
MedLine Citation:
PMID:  18626905     Owner:  NLM     Status:  MEDLINE    
Liver fibrosis is characterized by an excess of collagen fiber deposition, and it is known that Kupffer cells play an important role by immunomodulation of the toxic response. Methyl palmitate (MP) is an effective Kupffer cell inhibitor. The aim of this work was to evaluate the effect of MP on experimental liver fibrosis. Four groups were formed: the control group, which received the vehicles only; CCl(4) group (0.4 g kg(-1), i.p., three times a week, for eight weeks); CCl(4) plus MP (300 mg kg(-1), i.p., daily); and MP alone. Alanine aminotransferase was increased by CCl(4), and MP did not prevent this increase. Lipid peroxidation was increased markedly by CCl(4); again, MP was not able to prevent this effect. Fibrosis increased nearly 6-fold (measured as liver hydroxyproline content) in the CCl(4) group; MP preserved the normal content of collagen. These results were corroborated by histopathology. To elucidate the antifibrogenic mechanism of MP, we measured the production of TGF-beta; CCl(4) increased this cytokine several-fold, and MP abolished this increase. Collectively the present results indicate that MP possesses a strong antifibrogenic effect at least in the CCl(4) model of fibrosis. The antifibrotic effect of MP is probably associated with its ability to reduce TGF-beta content, maybe by immunomodulation of Kupffer cells functioning.
Adriana Rodríguez-Rivera; Marina Galicia-Moreno; Karina Reyes-Gordillo; José Segovia; Paula Vergara; Mario G Moreno; Mineko Shibayama; Víctor Tsutsumi; Pablo Muriel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  28     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1021-6     Citation Subset:  IM    
Sección Externa de Farmacología, Cinvestav-IPN, México, D.F., México.
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MeSH Terms
Biotransformation / drug effects
Blotting, Western
Carbon Tetrachloride / metabolism,  toxicity
Carbon Tetrachloride Poisoning / pathology,  prevention & control*
Collagen / analysis,  metabolism
Down-Regulation / drug effects
Lipid Peroxidation / drug effects
Liver Cirrhosis / chemically induced,  pathology,  prevention & control*
Palmitates / pharmacology*
Rats, Wistar
Transforming Growth Factor beta / metabolism
Reg. No./Substance:
0/Palmitates; 0/Transforming Growth Factor beta; 112-39-0/methyl palmitate; 56-23-5/Carbon Tetrachloride; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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