| Methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside: an inhibitor of sweet taste responses in gerbils. | |
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MedLine Citation:
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PMID: 6849141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sugar methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside (DiCl-gal) is a new type of inhibitor of the gerbil's electrophysiological taste response to sucrose or saccharin. Saturated solutions of this compound alone barely stimulate the gerbil's taste nerve. But, when mixed with sucrose or saccharin, DiCl-gal suppresses the gerbil's taste response to these two sweeteners. In contrast, when mixed with sodium chloride or hydrochloric acid, DiCl-gal does not affect the taste responses to these compounds. However, unlike other inhibitors of sweet taste, the DiCl-gal taste suppression is short-lived and occurs only when the inhibitor is combined with the sweetener. |
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Authors:
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W Jakinovich |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 219 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-02-25 Completed Date: 1983-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 408-10 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Gerbillinae Methylgalactosides* / pharmacology* Methylglycosides* / pharmacology* Sodium Chloride Sweetening Agents Taste / drug effects* Taste Buds / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS16022-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methylgalactosides; 0/Methylglycosides; 0/Sweetening Agents; 4990-82-3/methyl 4,6-dichloro-4,6-dideoxy-alpha-galactopyranoside; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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