Document Detail


Methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside: an inhibitor of sweet taste responses in gerbils.
MedLine Citation:
PMID:  6849141     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sugar methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside (DiCl-gal) is a new type of inhibitor of the gerbil's electrophysiological taste response to sucrose or saccharin. Saturated solutions of this compound alone barely stimulate the gerbil's taste nerve. But, when mixed with sucrose or saccharin, DiCl-gal suppresses the gerbil's taste response to these two sweeteners. In contrast, when mixed with sodium chloride or hydrochloric acid, DiCl-gal does not affect the taste responses to these compounds. However, unlike other inhibitors of sweet taste, the DiCl-gal taste suppression is short-lived and occurs only when the inhibitor is combined with the sweetener.
Authors:
W Jakinovich
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  219     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  408-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Gerbillinae
Methylgalactosides* / pharmacology*
Methylglycosides* / pharmacology*
Sodium Chloride
Sweetening Agents
Taste / drug effects*
Taste Buds / drug effects
Grant Support
ID/Acronym/Agency:
R01 NS16022-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Methylgalactosides; 0/Methylglycosides; 0/Sweetening Agents; 4990-82-3/methyl 4,6-dichloro-4,6-dideoxy-alpha-galactopyranoside; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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