Document Detail


[Methyl 3, 4-dihydroxyphenylacetate prevents enterovirus 71 proliferation in rhabdomyosarcoma cells].
MedLine Citation:
PMID:  23227560     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This article presented the inhibitory activity of methyl 3, 4-dihydroxyphenylacetate on the enterovirus 71 (EV71) infection. The EV71 VP1 capsid protein expression levels were analyzed with Western blotting. Results revealed that the compound is able to inhibit EV71 replication in rhabdomyosarcoma (RD) cells. After being incubated with the compound at a concentration of 0.01 microg x microL(-1) for 48 h, the level of EV71 vp1 mRNA in RD cells decreased by (76.83 +/- 2.47)%. The cytotoxic activity of the compound was evaluated against RD cells by a MTT assay. The results showed that the compound had low toxicity with a CC50 of 0.072 6 microg x microL(-1). These findings suggest that methyl 3, 4-dihydroxyphenylacetate is a novel compound for antiviral therapies against EV71, which merited further investigation.
Authors:
Ying-Qiu Zhang; Chun-Hui Zhao; Zhuo Yang
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Yao xue xue bao = Acta pharmaceutica Sinica     Volume:  47     ISSN:  0513-4870     ISO Abbreviation:  Yao Xue Xue Bao     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21710340R     Medline TA:  Yao Xue Xue Bao     Country:  China    
Other Details:
Languages:  chi     Pagination:  1257-60     Citation Subset:  IM    
Affiliation:
School of Life Science, Liaoning Normal University, Dalian 116029, China.
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