Document Detail


Methoxychlor accelerates embryo transport through the rat reproductive tract.
MedLine Citation:
PMID:  2296764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The estrogenic pesticide methoxychlor (MXC) is known to reduce implantation, and, in our previous work, this reduction has been attributed to a direct effect on uterine function. The present study was designed to investigate the effect of MXC on embryo transport rate, another phenomenon that is vulnerable to estrogenic effects. MXC was administered by gavage, at 0, 100, 200, and 500 mg/kg/day, to groups of rats on Days 1-3 of pregnancy (Day 0 = sperm positive), and the distribution of embryos in the oviducts and uteri of animals was assessed at five time intervals prior to implantation. No effect of MXC was detected by the afternoon of Day 1. On Days 2 and 3 of pregnancy, 200 and 500 mg/kg/day MXC were found to accelerate embryo transport into the uterus; the 500 mg/kg/day dosage also reduced the total number of embryos recovered from the tract. On the third day, 100 mg/kg/day MXC also accelerated embryo transport to the uterus and 200 mg/kg/day MXC reduced total embryo recovery. Until the afternoon of Day 3, most control embryos remained in the oviduct. These data demonstrate that MXC produces a dose-dependent acceleration of embryo transport through the female reproductive tract. When compared with previous work, the current data indicate that such an acceleration is the primary cause of MXC-induced preimplantation embryonic loss when exposure occurs after fertilization.
Authors:
A M Cummings; S D Perreault
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  102     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  110-6     Citation Subset:  IM    
Affiliation:
Developmental Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / drug effects*,  physiology
Dose-Response Relationship, Drug
Embryonic Development / drug effects,  physiology
Estrus / drug effects
Female
Methoxychlor / toxicity*
Pregnancy
Rats
Time Factors
Chemical
Reg. No./Substance:
72-43-5/Methoxychlor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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