Document Detail

Methotrexate treatment for cervical pregnancy: experience of four cases.
MedLine Citation:
PMID:  7691303     Owner:  NLM     Status:  MEDLINE    
Although cervical pregnancies account for a very small number of the ectopic pregnancies, they sometimes result in a tragic outcome due to the difficulty of surgical treatment and subsequent intractable hemorrhage. We report our experience with four cases of cervical pregnancy which were treated successfully with methotrexate. All four patients had a history of a previous abortion and two had previously had a cesarean section. High-resolution transabdominal and transvaginal color Doppler ultrasound was used for diagnosis, and the serial beta-human chorionic gonadotropin levels were checked to monitor the therapeutic effect. Hysterectomy was avoided, and the reproductive capability of these patients was preserved. Chemotherapy was well tolerated except for mild stomatitis in one case and a transient elevation of liver enzymes in another case. One patient delivered a healthy female infant two years after treatment. In conclusion, previous curettage and a low segment cesarean section may contribute to the development of a cervical pregnancy. Fortunately, methotrexate therapy offers an effective nonsurgical treatment for this potentially catastrophic condition.
K H Chao; M K Shyu; G T Juang; F J Hsieh; H Y Chen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  92     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  HONG KONG    
Other Details:
Languages:  eng     Pagination:  426-30     Citation Subset:  IM    
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, R.O.C.
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MeSH Terms
Cervix Uteri
Chorionic Gonadotropin / blood
Chorionic Gonadotropin, beta Subunit, Human
Methotrexate / therapeutic use*
Peptide Fragments / blood
Pregnancy, Ectopic / drug therapy*,  ultrasonography
Ultrasonography, Prenatal
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments; 59-05-2/Methotrexate

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