Document Detail

Methotrexate pneumonitis in a psoriatic.
MedLine Citation:
PMID:  1191523     Owner:  NLM     Status:  MEDLINE    
A life-threatening respiratory disease, characterized by fever, cough, dyspnoea, cyanosis and wide-spread bilateral pulmonary infiltrates, developed in a 40-year-old patient receiving intermittent methotrexate therapy for psoriasis. Blood eosinophilia accompanied the illness. A prominent feature in the clinical picture was a discrepancy between auscultatory findings and the pronounced changes in the chest X-ray. Systemic corticosteroids produced rapid improvement. It is suggested that the pulmonary syndrome represents a hypersensitivity reaction.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  93     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1976-02-13     Completed Date:  1976-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
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MeSH Terms
Drug Hypersensitivity*
Dyspnea / chemically induced
Eosinophilia / chemically induced
Methotrexate / adverse effects*,  therapeutic use
Pneumonia / chemically induced*,  radiography
Psoriasis / drug therapy*
Reg. No./Substance:

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