Document Detail


Methotrexate: the pharmacology behind medical treatment for ectopic pregnancy.
MedLine Citation:
PMID:  22510625     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Previously established as a chemotherapeutic agent for decades, methotrexate has been adapted for use as a medical therapy for unruptured ectopic pregnancies. Its mechanism of action, competitive inhibition of folate-dependent steps in nucleic acid synthesis, effectively kills the rapidly dividing ectopic trophoblast. However, the same action on normal cells is the basis for many of its adverse effects.
Authors:
Catherine S Stika
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  55     ISSN:  1532-5520     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  433-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
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