| Methotrexate: the pharmacology behind medical treatment for ectopic pregnancy. | |
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MedLine Citation:
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PMID: 22510625 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Previously established as a chemotherapeutic agent for decades, methotrexate has been adapted for use as a medical therapy for unruptured ectopic pregnancies. Its mechanism of action, competitive inhibition of folate-dependent steps in nucleic acid synthesis, effectively kills the rapidly dividing ectopic trophoblast. However, the same action on normal cells is the basis for many of its adverse effects. |
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Authors:
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Catherine S Stika |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical obstetrics and gynecology Volume: 55 ISSN: 1532-5520 ISO Abbreviation: Clin Obstet Gynecol Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0070014 Medline TA: Clin Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 433-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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