| Methotrexate in psoriatic polyarthritis. | |
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MedLine Citation:
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PMID: 8073807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methotrexate (MTX) is widely accepted as an effective treatment for psoriasis and chronic polyarthrides. We report data from 54 psoriatic polyarthritis patients (354 encounters) treated with MTX. 65% were males, mean age 47.9 years, mean disease duration 9.8 years for arthritis, 14.2 years for psoriasis. The MTX dose was 10-12.5 mg/week. 32 patients are still on MTX after a mean treatment time of 1.6 years. 22 patients discontinued MTX treatment: 11 felt it to be ineffective, in 6 patients there were side effects, 3 patients obtained remission, while 2 patients underwent surgery. Efficacy was good on the whole: number of swollen and tender joints, global disease activity score, ESR, and CRP all underwent a significant reduction. The intake of symptomatic drugs was reduced in 40%. Psoriasis as assessed with the Psoriasis Activity and Severity Index showed a significant improvement. Our data confirm that MTX is of value in most psoriatic polyarthritis patients (60%). In our experience, this drug, gives the maximum efficacy within 6 months of therapy. |
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Authors:
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P D Pigatto; E Gibelli; R Ranza; A Rossetti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica. Supplementum Volume: 186 ISSN: 0365-8341 ISO Abbreviation: Acta Derm Venereol Suppl (Stockh) Publication Date: 1994 |
Date Detail:
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Created Date: 1994-09-23 Completed Date: 1994-09-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370311 Medline TA: Acta Derm Venereol Suppl (Stockh) Country: NORWAY |
Other Details:
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Languages: eng Pagination: 114-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Psoriatic
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drug therapy* Female Humans Male Methotrexate / therapeutic use* Middle Aged |
| Chemical | |
Reg. No./Substance:
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59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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