Document Detail


Methotrexate in psoriatic polyarthritis.
MedLine Citation:
PMID:  8073807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methotrexate (MTX) is widely accepted as an effective treatment for psoriasis and chronic polyarthrides. We report data from 54 psoriatic polyarthritis patients (354 encounters) treated with MTX. 65% were males, mean age 47.9 years, mean disease duration 9.8 years for arthritis, 14.2 years for psoriasis. The MTX dose was 10-12.5 mg/week. 32 patients are still on MTX after a mean treatment time of 1.6 years. 22 patients discontinued MTX treatment: 11 felt it to be ineffective, in 6 patients there were side effects, 3 patients obtained remission, while 2 patients underwent surgery. Efficacy was good on the whole: number of swollen and tender joints, global disease activity score, ESR, and CRP all underwent a significant reduction. The intake of symptomatic drugs was reduced in 40%. Psoriasis as assessed with the Psoriasis Activity and Severity Index showed a significant improvement. Our data confirm that MTX is of value in most psoriatic polyarthritis patients (60%). In our experience, this drug, gives the maximum efficacy within 6 months of therapy.
Authors:
P D Pigatto; E Gibelli; R Ranza; A Rossetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica. Supplementum     Volume:  186     ISSN:  0365-8341     ISO Abbreviation:  Acta Derm Venereol Suppl (Stockh)     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-23     Completed Date:  1994-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370311     Medline TA:  Acta Derm Venereol Suppl (Stockh)     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  114-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Psoriatic / drug therapy*
Female
Humans
Male
Methotrexate / therapeutic use*
Middle Aged
Chemical
Reg. No./Substance:
59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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