Document Detail

Methotrexate in primary Sjögren's syndrome.
MedLine Citation:
PMID:  8913659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the safety and efficacy of methotrexate (MTX) in the treatment of primary Sjögren's syndrome (SS). METHODS: An open, one-year pilot study of MTX (0.2 mg/kg body weight taken weekly) for the treatment of SS was performed. Seventeen patients with primary SS according to EEC criteria were enrolled in the study. Outcome was determined on the basis of clinical and laboratory parameters. RESULTS: Weekly administration of MTX resulted in improvement of the main subjective symptoms (dry mouth and eyes) as well as in the frequency of parotid gland enlargement, dry cough and purpura. However, no improvement in the objective parameters of dry eyes and dry mouth were observed. Persistent asymptomatic elevation of the hepatic transaminase levels led to a dosage reduction in 7 patients (41%). CONCLUSIONS: Weekly MTX may be an acceptable form of therapy for SS patients. Double-blind trials are needed to substantiate the efficacy of this therapeutic modality.
F N Skopouli; P Jagiello; N Tsifetaki; H M Moutsopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  14     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1997-02-20     Completed Date:  1997-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  555-8     Citation Subset:  IM    
Department of Medicine, Medical School of Ioannina, Greece.
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MeSH Terms
Administration, Oral
Antirheumatic Agents / administration & dosage,  therapeutic use*
Methotrexate / administration & dosage,  therapeutic use*
Middle Aged
Pilot Projects
Sjogren's Syndrome / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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