| Methotrexate in primary Sjögren's syndrome. | |
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MedLine Citation:
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PMID: 8913659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the safety and efficacy of methotrexate (MTX) in the treatment of primary Sjögren's syndrome (SS). METHODS: An open, one-year pilot study of MTX (0.2 mg/kg body weight taken weekly) for the treatment of SS was performed. Seventeen patients with primary SS according to EEC criteria were enrolled in the study. Outcome was determined on the basis of clinical and laboratory parameters. RESULTS: Weekly administration of MTX resulted in improvement of the main subjective symptoms (dry mouth and eyes) as well as in the frequency of parotid gland enlargement, dry cough and purpura. However, no improvement in the objective parameters of dry eyes and dry mouth were observed. Persistent asymptomatic elevation of the hepatic transaminase levels led to a dosage reduction in 7 patients (41%). CONCLUSIONS: Weekly MTX may be an acceptable form of therapy for SS patients. Double-blind trials are needed to substantiate the efficacy of this therapeutic modality. |
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Authors:
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F N Skopouli; P Jagiello; N Tsifetaki; H M Moutsopoulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 14 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 1996 Sep-Oct |
Date Detail:
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Created Date: 1997-02-20 Completed Date: 1997-02-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: ITALY |
Other Details:
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Languages: eng Pagination: 555-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Medical School of Ioannina, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Antirheumatic Agents / administration & dosage, therapeutic use* Female Humans Male Methotrexate / administration & dosage, therapeutic use* Middle Aged Pilot Projects Sjogren's Syndrome / drug therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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