Document Detail

Methotrexate for abortion at < or = 42 days gestation.
MedLine Citation:
PMID:  8131393     Owner:  NLM     Status:  MEDLINE    
Methotrexate is cytotoxic to trophoblast and, in low doses, has minimal side effects. It is used to treat gestational trophoblastic neoplasia and ectopic pregnancy and has recently been shown to have similar effects on intrauterine trophoblast. A prior study suggested that methotrexate may successfully cause abortion of an early pregnancy without prostaglandin. To test this hypothesis, ten pregnant women at < or = 42 days gestation were treated with methotrexate 50 mg/m2 intramuscularly. Vaginal bleeding started 24 +/- 10 (mean +/- standard deviation) days after the injection and lasted 10 +/- 3 days. Methotrexate side effects occurred in 4 patients and were limited to the first 4 days after the injection. Methotrexate alone appears sufficient to abort a very early intrauterine pregnancy.
M D Creinin
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Contraception     Volume:  48     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-15     Completed Date:  1994-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco General Hospital 94110.
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MeSH Terms
Abortifacient Agents, Nonsteroidal* / administration & dosage,  adverse effects
Abortion, Induced*
Methotrexate* / administration & dosage,  adverse effects
Prospective Studies
Time Factors
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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