| Methotrexate for abortion at < or = 42 days gestation. | |
| | |
MedLine Citation:
|
PMID: 8131393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Methotrexate is cytotoxic to trophoblast and, in low doses, has minimal side effects. It is used to treat gestational trophoblastic neoplasia and ectopic pregnancy and has recently been shown to have similar effects on intrauterine trophoblast. A prior study suggested that methotrexate may successfully cause abortion of an early pregnancy without prostaglandin. To test this hypothesis, ten pregnant women at < or = 42 days gestation were treated with methotrexate 50 mg/m2 intramuscularly. Vaginal bleeding started 24 +/- 10 (mean +/- standard deviation) days after the injection and lasted 10 +/- 3 days. Methotrexate side effects occurred in 4 patients and were limited to the first 4 days after the injection. Methotrexate alone appears sufficient to abort a very early intrauterine pregnancy. |
| | |
Authors:
|
M D Creinin |
Related Documents
:
|
11172133 - Three conservative approaches to treatment of interstitial pregnancy. 16036203 - Hysteroscopic management of cesarean scar pregnancy after unsuccessful methotrexate tre... 10451523 - Fetal nuchal translucency and prenatal diagnosis of beta-thalassaemia. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Contraception Volume: 48 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 1993 Dec |
Date Detail:
|
Created Date: 1994-04-15 Completed Date: 1994-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0234361 Medline TA: Contraception Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 519-25 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco General Hospital 94110. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortifacient Agents, Nonsteroidal*
/
administration & dosage,
adverse effects Abortion, Induced* Adult Female Humans Methotrexate* / administration & dosage, adverse effects Pregnancy Prospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A systematic assessment of the comorbidity of DSM-III-R personality disorders in alcoholic outpatien...
Next Document: THe "U" technique: a new method for Norplant implants removal.