Document Detail


Methoprene and 20-OH-ecdysone affect male production in Daphnia pulex.
MedLine Citation:
PMID:  11349860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure of Daphnia pulex to the insecticide and juvenile hormone-mimic methoprene resulted in a decrease in the incidence of all-male broods and an increase in the incidence of all-female broods compared with controls. These effects were observed at nominal concentrations of 10 and 100 microg/L, within the upper range of concentrations at which methoprene is applied in the environment. Because methoprene has been found to bind to the mammalian retinoid X receptor, we also tested the effects of retinoic acid on Daphnia reproduction. Neither 9-cis-retinoic acid nor all-trans-retinoic acid had any observable effect. Because juvenile hormone and ecdysteroids interact in many insect systems, we also exposed Daphnia to 20-OH-ecdysone. Exposure to the crustacean hormone 20-OH-ecdysone at levels of 1 and 10 microg/L resulted in an increase in all-male broods and a decrease in all-female broods, but 100 microg/L 20-OH-ecdysone resulted in a decrease in all-male broods and an increase in all-female broods. Our results suggest that juvenile hormone and ecdysteroids might play a role in the Daphnia sex determination system.
Authors:
J K Peterson; D R Kashian; S I Dodson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  20     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-14     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  582-8     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Wisconsin, Madison 53706-1381, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Daphnia / drug effects*,  growth & development
Ecdysterone / pharmacology*
Female
Male
Methoprene / pharmacology*
Random Allocation
Sex Ratio*
Tretinoin / pharmacology
Chemical
Reg. No./Substance:
302-79-4/Tretinoin; 40596-69-8/Methoprene; 5289-74-7/Ecdysterone; 5300-03-8/alitretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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