Document Detail


Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle
MedLine Citation:
PMID:  16450702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Improvements of animal health, welfare and product quality are major goals of modern animal breeding. Thus, in addition to the classical production traits, functional traits such as disease resistance, fertility and longevity moved into the center of animal breeder's interests. Due to their low heritability, the improvement of functional traits using conventional approaches of phenotypic testing and quantitative genetics is difficult. A number of studies have been conducted worldwide in various species to map quantitative trait loci (QTLs) and to identify genetic markers for health traits. This has revealed a plethora of chromosome regions which may harbor genes with relevance for animal health. Functional genome research integrates holistic investigations at the level of the genome, at the level of gene activity (transcriptome, proteome) and at various levels of phenotypic expression. The integration of all these levels of information provides the basis for the functional dissection of complex traits. This review provides an overview of the most important strategies for holistic transcriptome and proteome analyses. The successful application of these techniques is exemplified by our studies of bovine reproductive biology.
Authors:
Eckhard Wolf; Stefan Hiendleder; Stefan Bauersachs; Thomas Fröhlich; Fred Sinowatz; Helmut Blum; Georg J Arnold
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Berliner und Münchener tierärztliche Wochenschrift     Volume:  119     ISSN:  0005-9366     ISO Abbreviation:  Berl. Munch. Tierarztl. Wochenschr.     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0003163     Medline TA:  Berl Munch Tierarztl Wochenschr     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  7-16     Citation Subset:  IM    
Affiliation:
Lehrstuhl für MolekulareTierzucht und Biotechnologie, Ludwig-Maximilians-Universität München. ewolf@lmb.uni-muenchen.de
Vernacular Title:
Methoden der Transkriptom- und Proteomanalyse: Anwendung für repro- duktionsbiologische Fragestellungen beim Rind.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle / genetics*,  physiology*
Chromosome Mapping
Female
Gene Expression Profiling / veterinary
Gene Expression Regulation
Genetic Markers
Genome
Male
Oligonucleotide Array Sequence Analysis / veterinary
Proteome
Proteomics*
Quantitative Trait Loci*
Reproduction / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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