| Methods to increase the success rate of artificial insemination with donor semen. | |
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MedLine Citation:
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PMID: 8046019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Donor insemination was performed in two fertility clinics using cryopreserved semen from the same sperm bank. Donors were selected in agreement with American Fertility Society recommendations. In the first clinic, cup insemination was combined with intra-uterine insemination in 321 cycles. Follicular development was closely monitored with vaginal echography and serum hormonal measurements. In the second clinic, 1287 insemination cycles were performed using intra-cervical insemination, timed only on basal body temperature. In the first clinic, a total of 53 pregnancies were obtained, of which seven were in 55 unstimulated cycles (12.5%), 21 in 159 cycles with clomiphene citrate stimulation (13.1%, P > 0.1), and 25 in 107 cycles stimulated with clomiphene plus human menopausal gonadotrophin (HMG) (23.9%, P < 0.03). No multiple pregnancies were observed in the latter group. In the second clinic, 159 pregnancies occurred during 1287 insemination cycles (12.4%). It is concluded that neither intra-uterine insemination, nor hormonal and echographic cycle monitoring, nor clomiphene citrate enhances the success rate of artificial insemination with donor semen, but HMG treatment probably exerts a favourable effect. |
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Authors:
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H T Depypere; S Gordts; R Campo; F Comhaire |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 9 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-09-01 Completed Date: 1994-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 661-3 Citation Subset: IM |
Affiliation:
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Department of Gynaecology, University Hospital, Ghent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Clomiphene / therapeutic use Cryopreservation Estradiol / blood Female Humans Infertility, Male Insemination, Artificial, Heterologous* Male Menotropins / therapeutic use Ovarian Follicle / physiology, ultrasonography Pregnancy Semen* Semen Preservation Sperm Motility |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 61489-71-2/Menotropins; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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